Correlation of CBC Parameters and Immunophenotyping in Acute Lymphoblastic Leukaemia Patients in Khartoum State, Sudan
Mohanad Abdelghafar Abdelaziz Elsheikh1, Albaraa Abdulfatah Mohammed1, Ghanem Mohammed Mahjaf2, Tibyan Abd Almajed Altaher3, Mayada Mansoor Seliman Abdalla4, Mosab Nouraldein Mohammed Hamad5*
1Department of Haematology and Immunohematology, Faculty of Medical Laboratory Sciences, National University, Sudan.
2Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Shendi University, Shendi, Sudan.
3Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Shendi University, Sudan.
4Department of Haematology and Immunohematology, Faculty of Medical Laboratory Sciences, Shendi University, Sudan.
5Assistant professor, Microbiology department, Faculty of Medicine, Elsheikh Abdallah Elbadri University, Sudan.
Corresponding author: Mosab Nouraldein Mohammed Hamad
Assistant professor, Microbiology department, Faculty of Medicine, Elsheikh Abdallah Elbadri University, Sudan.
Corresponding Email: musab.noor13@gmail.com
Abstract:
Background: Acute lymphoblastic leukemia, a malignant disorder of lymphoid progenitor cells, affects both children and adults, with peak prevalence between the ages of 2 and 5 years. Objectives: This study aimed to estimate the complete blood count and immunophenotyping and correlate the parameter results among acute lymphoblastic leukemia Sudanese patients. Methods: An analytical cross-sectional study was conducted in Khartoum Hospital for Oncology and Flow Cytometry Centre from January to April 2023 on a total of one hundred fifty venous blood samples collected from acute lymphoblastic leukemia patients. A complete hemogram was then done using an automated cell counter (Mindray BC 6800) and flow cytometry. Results: For compassion of CBC between B cells and T cells type, WBCS was significantly higher in T cell type compared to B cell type (162.2 ± 25.0 vs 43.3 ± 4.8)p-value 0.000* respectively, RBCS did not significantly differ in T cell type and B cell type (2.7 ± 0.9 vs 2.7 ± 0.8)p-value 0.843, platelet was not significantly differed in T cell type and B cell type (45.4 ± 4.3 vs 51.3 ± 7.2)p-value 0.525 respectively, HB did not significantly differ in T cell type and B cell type (8.7 ± 0.6 vs 8.7 ± 0.6)p-value 0.942 respectively, Blast was not significantly differed in T cell type and B cell type (68.3 ± 19.6 vs 60.9 ± 18.3) p-value 0.052, For correlations of age with CBC, all parameters were not significantly correlated with age. Conclusion: The study concludes that anemia and thrombocytopenia were observed in almost all patients, white blood cells were significantly higher in the T cell type compared to the B cell type.Keywords: Acute Lymphoblastic Leukemia, Correlation, CBC, Immunophenotyping, Laboratory parameters, Sudan
