Detection of Factor V Leiden among Sudanese Acute Lymphoblastic Leukemia Patients at Khartoum state, 2023

Elshemaa Mohamed Bakur Mohamed¹, Albaraa Abdulfatah Mohammed², Ghanem Mohammed Mahjaf³, Tibyan Abd Almajed Altaher⁴, Mayada Mansoor Seliman Abdalla⁵, Mosab Nouraldein Mohammed Hamad^6*

¹Department of Haematology and Immunohematology, Faculty of Medical Laboratory Sciences, National University, Sudan.

²Associate professor, Hematology Department,  Alfajr College for science and Technology, Sudan

³Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Shendi University, Shendi, Sudan.

⁴Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Shendi University, Sudan.

⁵Department of Haematology and Immunohematology, Faculty of Medical Laboratory Sciences, Shendi University, Sudan.

⁶Assistant professor, Microbiology department, Faculty of Medicine, Elsheikh Abdallah Elbadri University, Sudan.

Corresponding author:  mosab@eaeu.edu.sd

Abstract:

Background: Factor V Leiden is an inherited disorder in which hemostatic balance tends towards thrombophilia blood clotting. Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels, which represents an increase in rates of thrombophilic morbidity and, when found in acute lymphoblastic leukemia patients, increases the risk of thrombotic events. The study was designed to detect Factor V Leiden in ALL Sudanese patients. Material and method: This was a descriptive case-control study. A total of one hundred (100) participants were included in this study after their approval had been acquired. 50 ALL patients were enrolled as case groups, and 50 as control groups. The detection of Factor V Leiden was done using conventional PCR. This study was conducted from January to March in Khartoum State. Results: The investigation revealed that out of 50 patients, none of them had the Factor V Leiden mutation, and the control group also had no mutation. Conclusion: According to the results of this study, the factor V Leiden mutation was not detected in ALL Sudanese patients. No association was observed between factor V and ALL.Keywords: Factor V Leiden, Detection, ALL, leukemia